Two statements in respect of drug-enzyme interaction are given below
Statement I: Action of an enzyme can be blocked only when an inhibitor blocks the active site of the enzyme.
Statement II: An inhibitor can form a strong covalent bond with the enzyme.
In the light of the above statements, Choose the correct answer from the options given below
Statement I: Action of an enzyme can be blocked only when an inhibitor blocks the active site of the enzyme.
Statement II: An inhibitor can form a strong covalent bond with the enzyme.
In the light of the above statements, Choose the correct answer from the options given below
- (A)Both Statement I and Statement II are true
- (B)Both Statement I and Statement II are false
- (C)Statement I is true but Statement II is false
- (D)Statement I is false but Statement II is true✓ Correct
Answer: (D)
Solution
Statement I is false because enzyme action can be blocked not only by competitive inhibitors at the active site but also by allosteric inhibitors that bind to sites other than the active site (allosteric sites), causing conformational changes that reduce enzyme activity. Statement II is true because some inhibitors (irreversible inhibitors) form strong covalent bonds with the enzyme, permanently inactivating it. Therefore, Statement I is false but Statement II is true.
JEE Main · 2022 · 28 Jul 2022 · Shift 2 · Single correct option