JEE Main · 2019 · 08 Apr 2019 · Shift 2 · Coordination Compounds

The compound that inhibits the growth of tumors is:

(A)trans - $[Pd (Cl)_{2} (NH_{3})_{2}]$
(B)trans - $[Pt (Cl)_{2} (NH_{3})_{2}]$
(C)cis $- [Pd (Cl)_{2} (NH_{3})_{2}]$
(D)cis $- [Pt (Cl)_{2} (NH_{3})_{2}]$ ✓ Correct

Answer: (D)

Solution

Cisplatin, cis-

[Pt (Cl) X_{2} (NH X_{3}) X_{2}]

, is the well-known anticancer drug. Its activity comes from the two chloride ligands sitting next to each other in the cis arrangement: once inside the cell they are displaced by nitrogen atoms of neighbouring DNA bases, cross-linking the strands and blocking replication, which halts tumour growth. The trans platinum isomer and the palladium analogues lack this effect, so the tumour-inhibiting compound is cis-

[Pt (Cl) X_{2} (NH X_{3}) X_{2}]

JEE Main · 2019 · 08 Apr 2019 · Shift 2 · Single correct option

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